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KMID : 1003219980040010133
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Journal of Korean Oriental Chronic Disease
1998 Volume.4 No. 1 p.133 ~ p.162
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Effects of Kamiboyanghwanotang(KBHT) on hyperlipidemia, thrombosis, thrombosis, hyperviscosity, hypertension and brain damage
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Abstract
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For the evaluation of effects of KBHT A including Salviae Radix and Achyranthis Radix, KBHT B including Mori Ramulus to KBHT A, experiments were done on hyperlipidemia induced by administration of cholesterol, thrombosis by dextran, hyperviscosity, hypertension and brain damage.
The results were obtained as follows ;
1. In case of hyperlipidemia induced by cholesterol feed, serum cholesterol, triglyceride, and phospholipid were significantly decreased in both sample groups, while HDL-cholesterol and the number of platelets were significantly increased and also total lipid decreased only in sample B as compared with data of control.
2. In thrombosis by dextran, fibrinogen was significantly increased and aslo prothrombin time was significantly shortened in both sample groups, whereas numbers of platelet were significantly increased in sample A, but FDP was significantly decreased in sample B as compared with data of control.
3. In hyperviscosity by hydrocortisone acetate, fibrinogen, prothrombin time, viscosity of whole blood and serum were changed effectively with significance in both sample groups, while numbers of platelet and platelete aggregation were significantly increased in sample A and also hematocrit was decreased only in sample B as compared with data of control.
4. In experiment of hypertention, blood pressure was significnatly decreased in both sample groups on the first day after oral administration, while blood pressure was significnatly decreased in sample A on the 11th day after oral administration to SD rats as compared with data of control.
5. In damage of brain, shortening of coma duration by KCN, extension of suvival time to a lethal dose of KCN, extension of breathing time after decapitation and also after ligation of both common carotid arteries and extension of survival time after exposure to anoxia by Co2, N2 and vacuum pump were significantly exterted in both sample groups as compared with data of control.
Above results suggest KBHT including Salviae Radix and Achyranthis Radix or Mori Ramulus has the posssiblty to be effectively applied to the cerebrocardiac diseases such as CVA and coronay diseases, which also need more clinical and experimental studies in future.
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KEYWORD
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